{
  "meta": {
    "title": "RACap-POC synthetic biomedical knowledge graph",
    "status": "implemented-on-synthetic",
    "source": "Curated static sample for PY-01. No RA Capital internal data, no live Neo4j dependency.",
    "updated": "2026-07-03"
  },
  "nodes": [
    {
      "id": "co-asteria",
      "label": "Asteria Bio",
      "type": "company",
      "summary": "Synthetic immunology platform company used to demonstrate entity resolution."
    },
    {
      "id": "co-helixforge",
      "label": "HelixForge Therapeutics",
      "type": "company",
      "summary": "Synthetic oncology company with a targeted small-molecule program."
    },
    {
      "id": "co-nexoimmune",
      "label": "NexoImmune",
      "type": "company",
      "summary": "Synthetic immune-oncology company with a bispecific antibody program."
    },
    {
      "id": "co-lumenrna",
      "label": "LumenRNA",
      "type": "company",
      "summary": "Synthetic RNA-medicine company linked to pulmonary and rare-disease programs."
    },
    {
      "id": "co-orchidcell",
      "label": "OrchidCell",
      "type": "company",
      "summary": "Synthetic cell-therapy company used for mechanism-cluster examples."
    },
    {
      "id": "co-cygnus",
      "label": "Cygnus Complement",
      "type": "company",
      "summary": "Synthetic complement-biology company with hematology exposure."
    },
    {
      "id": "target-il17f",
      "label": "IL-17F",
      "type": "target",
      "summary": "Cytokine target represented here as a synthetic relationship endpoint."
    },
    {
      "id": "target-kras",
      "label": "KRAS G12D",
      "type": "target",
      "summary": "Oncology target used for synthetic mechanism and trial mapping."
    },
    {
      "id": "target-cd3",
      "label": "CD3",
      "type": "target",
      "summary": "T-cell-engaging target used in a synthetic bispecific program."
    },
    {
      "id": "target-c5ar1",
      "label": "C5aR1",
      "type": "target",
      "summary": "Complement-pathway target used for synthetic indication links."
    },
    {
      "id": "target-stat6",
      "label": "STAT6",
      "type": "target",
      "summary": "Transcription-factor target used for synthetic respiratory-disease mapping."
    },
    {
      "id": "target-bcma",
      "label": "BCMA",
      "type": "target",
      "summary": "Cell-therapy target used for a synthetic hematologic-oncology cluster."
    },
    {
      "id": "mech-cytokine",
      "label": "Selective cytokine blockade",
      "type": "mechanism",
      "summary": "Mechanism node joining target biology, indication, and company program context."
    },
    {
      "id": "mech-kras",
      "label": "Allosteric KRAS inhibition",
      "type": "mechanism",
      "summary": "Mechanism node for synthetic small-molecule oncology mapping."
    },
    {
      "id": "mech-tcell",
      "label": "T-cell redirection",
      "type": "mechanism",
      "summary": "Mechanism node for synthetic bispecific and cell-therapy programs."
    },
    {
      "id": "mech-complement",
      "label": "Complement pathway modulation",
      "type": "mechanism",
      "summary": "Mechanism node used to illustrate mechanism-cluster concentration."
    },
    {
      "id": "mech-rna",
      "label": "RNA expression tuning",
      "type": "mechanism",
      "summary": "Mechanism node for synthetic RNA-medicine mapping."
    },
    {
      "id": "ind-ad",
      "label": "Atopic dermatitis",
      "type": "indication",
      "summary": "Synthetic indication link; not a claim about any real company program."
    },
    {
      "id": "ind-pancreatic",
      "label": "Pancreatic cancer",
      "type": "indication",
      "summary": "Synthetic oncology indication for the KRAS cluster."
    },
    {
      "id": "ind-myeloma",
      "label": "Multiple myeloma",
      "type": "indication",
      "summary": "Synthetic hematologic-oncology indication."
    },
    {
      "id": "ind-pnh",
      "label": "PNH",
      "type": "indication",
      "summary": "Synthetic complement-biology indication."
    },
    {
      "id": "ind-asthma",
      "label": "Severe asthma",
      "type": "indication",
      "summary": "Synthetic respiratory indication."
    },
    {
      "id": "trial-ad-201",
      "label": "SYN-AD-201",
      "type": "trial",
      "summary": "Synthetic Phase 2 readout node with public-source-style provenance fields."
    },
    {
      "id": "trial-kras-110",
      "label": "SYN-KRAS-110",
      "type": "trial",
      "summary": "Synthetic first-in-human oncology trial node."
    },
    {
      "id": "trial-mm-302",
      "label": "SYN-MM-302",
      "type": "trial",
      "summary": "Synthetic registrational hematologic-oncology trial node."
    },
    {
      "id": "trial-pnh-040",
      "label": "SYN-PNH-040",
      "type": "trial",
      "summary": "Synthetic complement trial node."
    },
    {
      "id": "trial-asthma-088",
      "label": "SYN-ASTHMA-088",
      "type": "trial",
      "summary": "Synthetic respiratory trial node."
    }
  ],
  "links": [
    {
      "source": "co-asteria",
      "target": "target-il17f",
      "relation": "develops",
      "evidence": "Synthetic company pipeline page extraction"
    },
    {
      "source": "target-il17f",
      "target": "mech-cytokine",
      "relation": "participates_in",
      "evidence": "Synthetic literature abstract relation"
    },
    {
      "source": "mech-cytokine",
      "target": "ind-ad",
      "relation": "modulates",
      "evidence": "Synthetic disease-biology mapping"
    },
    {
      "source": "co-asteria",
      "target": "trial-ad-201",
      "relation": "sponsors",
      "evidence": "Synthetic trial-registry extraction"
    },
    {
      "source": "trial-ad-201",
      "target": "ind-ad",
      "relation": "enrolls_for",
      "evidence": "Synthetic trial-registry extraction"
    },
    {
      "source": "co-helixforge",
      "target": "target-kras",
      "relation": "develops",
      "evidence": "Synthetic company pipeline page extraction"
    },
    {
      "source": "target-kras",
      "target": "mech-kras",
      "relation": "participates_in",
      "evidence": "Synthetic literature abstract relation"
    },
    {
      "source": "mech-kras",
      "target": "ind-pancreatic",
      "relation": "modulates",
      "evidence": "Synthetic disease-biology mapping"
    },
    {
      "source": "co-helixforge",
      "target": "trial-kras-110",
      "relation": "sponsors",
      "evidence": "Synthetic trial-registry extraction"
    },
    {
      "source": "trial-kras-110",
      "target": "ind-pancreatic",
      "relation": "enrolls_for",
      "evidence": "Synthetic trial-registry extraction"
    },
    {
      "source": "co-nexoimmune",
      "target": "target-cd3",
      "relation": "develops",
      "evidence": "Synthetic company pipeline page extraction"
    },
    {
      "source": "target-cd3",
      "target": "mech-tcell",
      "relation": "participates_in",
      "evidence": "Synthetic mechanism extraction"
    },
    {
      "source": "mech-tcell",
      "target": "ind-myeloma",
      "relation": "modulates",
      "evidence": "Synthetic indication mapping"
    },
    {
      "source": "co-nexoimmune",
      "target": "trial-mm-302",
      "relation": "sponsors",
      "evidence": "Synthetic trial-registry extraction"
    },
    {
      "source": "trial-mm-302",
      "target": "ind-myeloma",
      "relation": "enrolls_for",
      "evidence": "Synthetic trial-registry extraction"
    },
    {
      "source": "co-orchidcell",
      "target": "target-bcma",
      "relation": "develops",
      "evidence": "Synthetic cell-therapy pipeline extraction"
    },
    {
      "source": "target-bcma",
      "target": "mech-tcell",
      "relation": "participates_in",
      "evidence": "Synthetic mechanism extraction"
    },
    {
      "source": "target-bcma",
      "target": "ind-myeloma",
      "relation": "associated_with",
      "evidence": "Synthetic indication mapping"
    },
    {
      "source": "co-cygnus",
      "target": "target-c5ar1",
      "relation": "develops",
      "evidence": "Synthetic company pipeline page extraction"
    },
    {
      "source": "target-c5ar1",
      "target": "mech-complement",
      "relation": "participates_in",
      "evidence": "Synthetic literature abstract relation"
    },
    {
      "source": "mech-complement",
      "target": "ind-pnh",
      "relation": "modulates",
      "evidence": "Synthetic indication mapping"
    },
    {
      "source": "co-cygnus",
      "target": "trial-pnh-040",
      "relation": "sponsors",
      "evidence": "Synthetic trial-registry extraction"
    },
    {
      "source": "trial-pnh-040",
      "target": "ind-pnh",
      "relation": "enrolls_for",
      "evidence": "Synthetic trial-registry extraction"
    },
    {
      "source": "co-lumenrna",
      "target": "target-stat6",
      "relation": "develops",
      "evidence": "Synthetic company pipeline page extraction"
    },
    {
      "source": "target-stat6",
      "target": "mech-rna",
      "relation": "participates_in",
      "evidence": "Synthetic RNA-program mapping"
    },
    {
      "source": "mech-rna",
      "target": "ind-asthma",
      "relation": "modulates",
      "evidence": "Synthetic disease-biology mapping"
    },
    {
      "source": "co-lumenrna",
      "target": "trial-asthma-088",
      "relation": "sponsors",
      "evidence": "Synthetic trial-registry extraction"
    },
    {
      "source": "trial-asthma-088",
      "target": "ind-asthma",
      "relation": "enrolls_for",
      "evidence": "Synthetic trial-registry extraction"
    },
    {
      "source": "co-asteria",
      "target": "co-lumenrna",
      "relation": "shares_indication_cluster",
      "evidence": "Synthetic portfolio-neighbor query"
    },
    {
      "source": "co-nexoimmune",
      "target": "co-orchidcell",
      "relation": "shares_mechanism_cluster",
      "evidence": "Synthetic mechanism-cluster query"
    }
  ]
}